However, careful selection of patients and monitoring the finasteride treatment may prevent the PFS to some extent. 2015 Sep;16(3):177-98. doi: 10.1007/s11154-015-9319-y. Of course there are some people with severe pfs but even then just wait is shit advice. A mod answered and I answered the guy in a normal way, but they deleted my reply and blocked my account. A review of the FAERS data on 5-alpha reductase inhibitors: implications for postfinasteride syndrome. What is infertility? Clipboard, Search History, and several other advanced features are temporarily unavailable. Just bombarding their bodies with strong androgens. For what it's worth, here's a couple similar success stories involving numbness, but from PSSD instead of PFS: Testosterone along with initial estrogen management , completely cured my pssd, everything from numbness, to hard on quality , no morning wood, to actually having sexual desires again. Will medications help me ejaculate normally? Their attitude is 100% there is no cure, it wont get better, nothing works, anything that does work doesnt work long term, and thats just how it is. Teeranachaideekul V, Parichatikanond W, Junyaprasert VB, Morakul B. Your doctor might also ask about any health problems, surgeries or cancers you've had and what medications you take. Disclaimer. My doctor put me on 5mg daily cialis (+up to 15mg as needed before sex) clomiphene 25mg/daily anastrozole 1mg/week Addyi shockwave therapy ($3000 for 6 sessions) though this is definitely unnecessary and experimental. Est. Like I said, almost starting to believe they want people to keep having pfs so they can benefit in some form or another. I know how I feel and I know it's working. And yeah I know hackstasis, looks to be a much better community and forum than propeciahelp without fascist mods. When did you first begin having dry orgasms? Careers. I was one of the lucky guys who recovered from Test injections, https://old.reddit.com/r/steroids/comments/igyd61/offtopic_daily_chat_20200826/g2ym80n/. ._3-SW6hQX6gXK9G4FM74obr{display:inline-block;vertical-align:text-bottom;width:16px;height:16px;font-size:16px;line-height:16px} ._1EPynDYoibfs7nDggdH7Gq{margin-bottom:8px;position:relative}._1EPynDYoibfs7nDggdH7Gq._3-0c12FCnHoLz34dQVveax{max-height:63px;overflow:hidden}._1zPvgKHteTOub9dKkvrOl4{font-family:Noto Sans,Arial,sans-serif;font-size:14px;line-height:21px;font-weight:400;word-wrap:break-word}._1dp4_svQVkkuV143AIEKsf{-ms-flex-align:baseline;align-items:baseline;background-color:var(--newCommunityTheme-body);bottom:-2px;display:-ms-flexbox;display:flex;-ms-flex-flow:row nowrap;flex-flow:row nowrap;padding-left:2px;position:absolute;right:-8px}._5VBcBVybCfosCzMJlXzC3{font-family:Noto Sans,Arial,sans-serif;font-size:14px;font-weight:400;line-height:21px;color:var(--newCommunityTheme-bodyText)}._3YNtuKT-Is6XUBvdluRTyI{position:relative;background-color:0;color:var(--newCommunityTheme-metaText);fill:var(--newCommunityTheme-metaText);border:0;padding:0 8px}._3YNtuKT-Is6XUBvdluRTyI:before{content:"";position:absolute;top:0;left:0;width:100%;height:100%;border-radius:9999px;background:var(--newCommunityTheme-metaText);opacity:0}._3YNtuKT-Is6XUBvdluRTyI:hover:before{opacity:.08}._3YNtuKT-Is6XUBvdluRTyI:focus{outline:none}._3YNtuKT-Is6XUBvdluRTyI:focus:before{opacity:.16}._3YNtuKT-Is6XUBvdluRTyI._2Z_0gYdq8Wr3FulRLZXC3e:before,._3YNtuKT-Is6XUBvdluRTyI:active:before{opacity:.24}._3YNtuKT-Is6XUBvdluRTyI:disabled,._3YNtuKT-Is6XUBvdluRTyI[data-disabled],._3YNtuKT-Is6XUBvdluRTyI[disabled]{cursor:not-allowed;filter:grayscale(1);background:none;color:var(--newCommunityTheme-metaTextAlpha50);fill:var(--newCommunityTheme-metaTextAlpha50)}._2ZTVnRPqdyKo1dA7Q7i4EL{transition:all .1s linear 0s}.k51Bu_pyEfHQF6AAhaKfS{transition:none}._2qi_L6gKnhyJ0ZxPmwbDFK{transition:all .1s linear 0s;display:block;background-color:var(--newCommunityTheme-field);border-radius:4px;padding:8px;margin-bottom:12px;margin-top:8px;border:1px solid var(--newCommunityTheme-canvas);cursor:pointer}._2qi_L6gKnhyJ0ZxPmwbDFK:focus{outline:none}._2qi_L6gKnhyJ0ZxPmwbDFK:hover{border:1px solid var(--newCommunityTheme-button)}._2qi_L6gKnhyJ0ZxPmwbDFK._3GG6tRGPPJiejLqt2AZfh4{transition:none;border:1px solid var(--newCommunityTheme-button)}.IzSmZckfdQu5YP9qCsdWO{cursor:pointer;transition:all .1s linear 0s}.IzSmZckfdQu5YP9qCsdWO ._1EPynDYoibfs7nDggdH7Gq{border:1px solid transparent;border-radius:4px;transition:all .1s linear 0s}.IzSmZckfdQu5YP9qCsdWO:hover ._1EPynDYoibfs7nDggdH7Gq{border:1px solid var(--newCommunityTheme-button);padding:4px}._1YvJWALkJ8iKZxUU53TeNO{font-size:12px;font-weight:700;line-height:16px;color:var(--newCommunityTheme-button)}._3adDzm8E3q64yWtEcs5XU7{display:-ms-flexbox;display:flex}._3adDzm8E3q64yWtEcs5XU7 ._3jyKpErOrdUDMh0RFq5V6f{-ms-flex:100%;flex:100%}._3adDzm8E3q64yWtEcs5XU7 .dqhlvajEe-qyxij0jNsi0{color:var(--newCommunityTheme-button)}._3adDzm8E3q64yWtEcs5XU7 ._12nHw-MGuz_r1dQx5YPM2v,._3adDzm8E3q64yWtEcs5XU7 .dqhlvajEe-qyxij0jNsi0{font-size:12px;font-weight:700;line-height:16px;cursor:pointer;-ms-flex-item-align:end;align-self:flex-end;-webkit-user-select:none;-ms-user-select:none;user-select:none}._3adDzm8E3q64yWtEcs5XU7 ._12nHw-MGuz_r1dQx5YPM2v{color:var(--newCommunityTheme-button);margin-right:8px;color:var(--newCommunityTheme-errorText)}._3zTJ9t4vNwm1NrIaZ35NS6{font-family:Noto Sans,Arial,sans-serif;font-size:14px;line-height:21px;font-weight:400;word-wrap:break-word;width:100%;padding:0;border:none;background-color:transparent;resize:none;outline:none;cursor:pointer;color:var(--newRedditTheme-bodyText)}._2JIiUcAdp9rIhjEbIjcuQ-{resize:none;cursor:auto}._2I2LpaEhGCzQ9inJMwliNO,._42Nh7O6pFcqnA6OZd3bOK{display:inline-block;margin-left:4px;vertical-align:middle}._42Nh7O6pFcqnA6OZd3bOK{fill:var(--newCommunityTheme-button);color:var(--newCommunityTheme-button);height:16px;width:16px;margin-bottom:2px} I recovered and I hope all of you suffering from PFS recover too. Effect of 5-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials. In some cases, sperm can be recovered from the bladder, processed in the laboratory and used to inseminate your partner (intrauterine insemination). Please enable it to take advantage of the complete set of features! Have you been on hackstasis? I have been prescribed a 2.5% DHT gel that is applied to the shoulders and forehead once a day. These hippocampal neurogenesis changes after finasteride treatment have been linked to emotional behavior and this might contribute to the pathophysiology of affective disorders in humans. AR: androgen receptor; CSF: cerebrospinal fluid; MRI: magnetic resonance imaging; SRD5A2: 5 alpha reductase type 2 gene. Even my genitals began to grow normal size again. A community dedicated to people suffering long term effects after taking 5-ar inhibitors such as Propecia/Finasteride, or for people who wish to know more about the constellation of symptoms commonly known as Post Finasteride Syndrome. This type of damage can be caused by diabetes, multiple sclerosis, certain surgeries, and other conditions and treatments. 2022 Oct;11(10):1452-1457. doi: 10.21037/tau-22-92. TRT so thats why I went down this rabbit hole. Next to no sensitivity in my genitals. Retrograde ejaculation typically doesn't require treatment unless it interferes with fertility. 2020 Jan;113(1):21-50. doi: 10.1016/j.fertnstert.2019.11.030. https://www.amazon.com/reviews/R3OGTPUQ1CP005. At some point you just cant store it all or want to use old drug. I only said everyone should read it, especially in light of the big new proviron recovery on the forum there. Indeed, some national agencies (e.g., Swedish Medical Products Agency, the Medicines and Healthcare Products Regulatory Agency of UK and the U.S. Food and Drug Administration) required to include multiple persistent side effects within the finasteride labels. Ive been doing this for over 2 years and have ZERO sexual side effects from the drug. Look, it's as simple as this. I'm not going to go into the entire history of what post finasteride syndrome is, and I assume many of you looking into buying Tribulus know exactly what it is. Depending on the likely cause of your dry orgasms and whether you need evaluation and treatment to help you get your female partner pregnant, you might need to see a urinary and reproductive specialist (urologist). No interest in sex at all. Int. Eliminate Trigger Foods. Please note the date of last review or update on all articles. For details, see text., Side effects of treatment with 5 alpha-reductase inhibitors in experimental models. It looked like it had been around the world a few times. This is because (in the USA) it is only approved for BPH at 5mg and insurance companies will reject claims when it is prescibed at 1mg, which is the only other available dosage. Accessed Sept. 15, 2016. Drugs that can cause retrograde ejaculation include certain medications for depression and alpha blockers drugs used to treat high blood pressure and some prostate conditions. Urology. 2022 Jul 27;15(8):930. doi: 10.3390/ph15080930. My life is finally back. This content does not have an Arabic version. Authors received funding from the Post-Finasteride Foundation in order to study PFS symptomatology of patients and in experimental models. When dosed properly, it can bring DHT within normal ranges very effectively. breast tenderness. ._1LHxa-yaHJwrPK8kuyv_Y4{width:100%}._1LHxa-yaHJwrPK8kuyv_Y4:hover ._31L3r0EWsU0weoMZvEJcUA{display:none}._1LHxa-yaHJwrPK8kuyv_Y4 ._31L3r0EWsU0weoMZvEJcUA,._1LHxa-yaHJwrPK8kuyv_Y4:hover ._11Zy7Yp4S1ZArNqhUQ0jZW{display:block}._1LHxa-yaHJwrPK8kuyv_Y4 ._11Zy7Yp4S1ZArNqhUQ0jZW{display:none} Maybe if theyre lucky in 10 years. Post-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or benign prostatic hyperplasia. Res. After stopping, I got ED, extreme fatigue, brain fog, no libido and lethargy. On PFS forums, peoples dicks got 1 inch bigger when erect, here and there, they sometimes felt sexual attraction towards women. The article stated proviron was the best potential cure in his opinion. there are many options including peptides, and HCG as well as clomid/arimidex. I think it took 6 months before i felt ready to meet a girl again. If so, how long have you been trying to conceive? I feel deeply for all my balding brothers out there who are suffering from this poison. Sign up now and get a FREE copy of theBest Diets for Cognitive Fitness. PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts. doi: 10.1016/j.urology.2018.06.022. Long term HCG treatment at high dosages can cause issues. and transmitted securely. Your doctor might ask: Mayo Clinic does not endorse companies or products. Archivio Istituzionale della Ricerca Unimi, NCI CPTC Antibody Characterization Program, Agis-Balboa R.C., Guidotti A., Pinna G. 5alpha-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients. An official website of the United States government. WebIn addition to the sexual, mental and physical side effects, PK suffers from miscellaneous issues connected with PFS. Mild side effects that have been reported with finasteride include: ejaculation problems. Accessibility I suspect that 2 mg would be adequate, but if my doc prescribes two 1mg pills per day, the insurance company wont pay for it because the 1mg pill is only approved for hair loss treatment. Yeah, that guy's comment history is really puzzling: When i dared visit PFS forums, the most miserable users there were still in a better state than me. The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting. Even Viagra wouldnt get me hard. When you are on TRT, your DHT levels tend to go out of the normal range and finasteride is a mechanism for bringing it back into range. I'm not a gym rat, I just make sure to walk 3-5 miles a day and do my best to watch what I eat (that's always been the case.) Crazy, but true! Over time, several studies have demonstrated that finasteride is a safe and well-tolerated drug, with rare and reversible side effects such as reduced sexual libido and ejaculatory volume, most commonly observed when prescribed in Im suffering from pfs for 3+ years now so pfs is very real sadly but I believe the dudes article is the best explenation Ive read so far. Urology. This procedure is usually done at the doctor's office. But on day 3, I felt like my old self. Make a list of all medications, vitamins and supplements that you're taking. In this review, we focused our attention on adverse events related to 5 alpha-reductase (5-R) inhibitors (i.e., finasteride and dutasteride), approved for the treatment of benign prostatic hyperplasia and androgenetic alopecia (AGA). Best, Dr. Emer. Mesterolone (Proviron) is one of the best compounds that can be used for treating Post Finasteride Syndrome in my opinion. Toxicol. As a 5-alpha reductase inhibitor, finasteride works by inhibiting the effects of the enzyme thats responsible for converting testosterone into dihydrotestosterone (DHT). They have some pretty smart people and are open to trying about anything, and isnt as negative as the other forum. WTF. Key takeaways: Finasteride is an FDA-approved medication that treats hair loss in men. However, minoxidil is used "off-label" for treating telogen effluvium, scarring alopecia and alopecia areata. Getting to the root cause of your hairloss would be the first thing to do as if you have an underlying medical condition, once thats treated, it could reverse the hairloss, so definately get a consultation with a physician to rule out anything treatable. https://forum.propeciahelp.com/t/my-story-yes-it-was-messy-and-yes-i-am-fine-now/5456. No active 34 year old man should have to be having ED discussions with his physician. 2011 Mar;8(3):872-84. doi: 10.1111/j.1743-6109.2010.02157.x. Note that prior to this protocol I tried injectable Test enanthate, Masteron, proviron and hcg which made my condition even worse. For details, see text. 2015;12:401. For each day that goes by, I get a day of surplus inventory. Liu L, Zhao S, Li F, Li E, Kang R, Luo L, Luo J, Wan S, Zhao Z. J Sex Med. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Mehta A, et al. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Book: Mayo Clinic Guide to Fertility and Conception. -. Althof HE, et al. Its H.C.G (HCG) dosed at 250IU Monday, Wednesday and Friday only. The guy who made this thread and gave his opinion was banned too. 2021 Dec 13;54(4):422-434. doi: 10.1055/s-0041-1739254. What the hell? The mods on that forum are fascists and dont allow the opinion and theory of other people. Ive read theres on guy there who recoverd recently from HCG, very interesting. Taking a vitamin D supplement or getting moderate sun exposure on a daily basis could be helpful in restoring your bodys vitamin D levels. People with post finasteride syndrome can have increased food sensitivities, extreme mood swings, and low energy levels. I just decided to get back on gear after a year off + dutasteride during that time. Are there other possible causes for my symptoms or condition? I am 100% reversed Keep in mind if I miss a dose or stop my protocol Pfs comes back full force. The Baylor study STILL hasnt been released? I dont really understand why theyre like that. 2012;97:306. Neuroactive steroid levels are modified in cerebrospinal fluid and plasma of post-finasteride patients showing persistent sexual side effects and anxious/depressive symptomatology. Make a donation. Understanding all of your options and communicating with your doctor and partner can help. Essentially I took testosterone exogenously And I took hcg afterwards, https://old.reddit.com/r/PSSD/comments/7lfc1e/how_i_fixed_my_pssd/. However, the side effects of a medication usually go away when you stop taking it. Should I be concerned? Last time I was on there they had started discussing some relationships between HCG and Thyroid? https://old.reddit.com/r/steroids/comments/m5m7o9/help_steroids_for_pssd/gr0uhqj/. This is a summary of the protocol which I followed for 6 months which eventually cured me. While most men can get their female partners pregnant with infertility treatment, it can be costly and require stressful medical procedures for both you and your partner. Jefferys A, et al. Bethesda, MD 20894, Web Policies No energy. ._2a172ppKObqWfRHr8eWBKV{-ms-flex-negative:0;flex-shrink:0;margin-right:8px}._39-woRduNuowN7G4JTW4I8{margin-top:12px}._136QdRzXkGKNtSQ-h1fUru{display:-ms-flexbox;display:flex;margin:8px 0;width:100%}.r51dfG6q3N-4exmkjHQg_{font-size:10px;font-weight:700;letter-spacing:.5px;line-height:12px;text-transform:uppercase;-ms-flex-pack:justify;justify-content:space-between;-ms-flex-align:center;align-items:center}.r51dfG6q3N-4exmkjHQg_,._2BnLYNBALzjH6p_ollJ-RF{display:-ms-flexbox;display:flex}._2BnLYNBALzjH6p_ollJ-RF{margin-left:auto}._1-25VxiIsZFVU88qFh-T8p{padding:0}._2nxyf8XcTi2UZsUInEAcPs._2nxyf8XcTi2UZsUInEAcPs{color:var(--newCommunityTheme-widgetColors-sidebarWidgetTextColor)} 8600 Rockville Pike WebPost-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or I am not aware or scientific evidence that back this up at this time. This after having PFS constantly for 11 years. I tried just about everything over 11 years. To be honest, I think for the most part these recoveries werent PFS but rather hormonal imbalances. Press question mark to learn the rest of the keyboard shortcuts. Sexual side effects: Loss of libido, impotence, testicular pain, testicle shrinkage, minor Peyronies (up to 10 degrees), penis pain, watery semen, Mental: Anxiety, insomnia, cognitive issues / brain fog. Therefore, I cut the pills in half (2.5mg) and toss the other half. Merck developed finasteride in the 1980s. Do you ever ejaculate semen when you have an orgasm, or do you have a dry orgasm every time? The .gov means its official. Write down key personal information, including prior surgeries or pelvic radiation, any major stresses, or recent life changes. Andracim Gel (small 2 eminem size, 1 on each size of rib cage, less is more with this stuff). These include: Prostate pain Persistent fatigue, exhaustion Stomach pains and digestive problems Constipation Blurry vision Propecia is the Biggest Regret of my Life Taking Propecia is the biggest regret of my life, PK said. Ran [Tbol] 250mg for 2 months increased the dosages anywhere from 500mg to 1000mg. Nature Reviews Urology. 12th ed. Sign up to get tips for living a healthy lifestyle, with ways to fight inflammation and improve cognitive health, plus the latest advances in preventative medicine, diet and exercise, pain relief, blood pressure and cholesterol management, andmore. https://forum.propeciahelp.com/t/i-think-im-healed-after-six-year-nightmare/35477. What medications or herbal remedies do you take? If youre experiencing a medical issue, please contact a healthcare professional or dial 911 immediately. Traish AM, Melcangi RC, Bortolato M, Garcia-Segura LM, Zitzmann M. Rev Endocr Metab Disord. Advise Me with Something Good I Can Do to my Hair. Epub 2010 Dec 22. Midodrine, a medicine that constricts blood vessels. But it is a risk men should discuss with their doctor prior to starting finasteride. Inability to concentrate. Day 2 I noticed a bit more energy, but credited that to having a good night's sleep (did I mention this stuff helps you sleep better, too?) Minoxidil is FDA approved for genetic hair loss - it does not help other conditions quite so much. I cycled herbal androgen boosting supplements combined with intense workouts (I am a bodybuilder). .FIYolDqalszTnjjNfThfT{max-width:256px;white-space:normal;text-align:center} Epub 2016 Jul 27. Side effects of treatment with 5 alpha-reductase inhibitors in experimental models. The drug reduces a testosterone-related hormone in certain tissues, including skin and the prostate gland. https://camas.github.io/reddit-search/#{%22author%22:%22mrgoodcat1990%22,%22resultSize%22:100,%22query%22:%22pssd%20numbness%22}, ._3K2ydhts9_ES4s9UpcXqBi{display:block;padding:0 16px;width:100%} Drugs to treat retrograde ejaculation are drugs primarily used to treat other conditions, including: These medications help keep the bladder neck muscle closed during ejaculation. Now and for the past six months, I feel great, my libido is great, mental issues are gone, ED is gone. Since your question stresses on age and since there might be other young people in their 20s and 30s who might find this question and come looking for answers, I thought I might start by pointing that out. Do a physical exam, which will likely include an exam of your penis, testicles and rectum. In some people with PFS, DHT might be normal, but testosterone and cortisol low and estrogen and prolactin high. Perhaps if I had tried it longer it would have helped more, Im not sure. Better to learn the cause of PFS and create a cure based on that. "I had a case of PFS that was a severe as it gets. Therefore, results here discussed indicate that PFS is an emerging clinical problem that needs to be further elucidated. I haven't had that sort of performance since I was 19 or 20 years old. Some people had to use anabolic steroids because herbs weren't strong enough. -, Baas W.R., Butcher M.J., Lwin A., Holland B., Herberts M., Clemons J., Delfino K., Althof S., Kohler T.S., McVary K.T. If your doctor thinks drugs you are taking might be affecting your ability to ejaculate normally, he or she might have you stop taking them for a period of time. I had a case of PFS that was a severe as it gets. After I got PFS my libido died, I stopped liking women, my brain wouldn't work, and my personality changed to a 90 old man. After 4 months of no progress whatsoever I tried the regimen that saved me - at least thats the only explanation I have. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. https://forum.propeciahelp.com/t/cured-after-11-years/42363. Mod also deleted my second post where I said he indeed has affiliate links to herbs but doesnt even believe that will be enough for pfs patients, the real cure is proviron, of course he doesnt have any affliate links to those products. In such cases, treatment depends on the underlying cause. Advertising revenue supports our not-for-profit mission. WebNeurogenesis was found to be reversed to normal 35 days after the last finasteride injection in male mice. @keyframes _1tIZttmhLdrIGrB-6VvZcT{0%{opacity:0}to{opacity:1}}._3uK2I0hi3JFTKnMUFHD2Pd,.HQ2VJViRjokXpRbJzPvvc{--infoTextTooltip-overflow-left:0px;font-size:12px;font-weight:500;line-height:16px;padding:3px 9px;position:absolute;border-radius:4px;margin-top:-6px;background:#000;color:#fff;animation:_1tIZttmhLdrIGrB-6VvZcT .5s step-end;z-index:100;white-space:pre-wrap}._3uK2I0hi3JFTKnMUFHD2Pd:after,.HQ2VJViRjokXpRbJzPvvc:after{content:"";position:absolute;top:100%;left:calc(50% - 4px - var(--infoTextTooltip-overflow-left));width:0;height:0;border-top:3px solid #000;border-left:4px solid transparent;border-right:4px solid transparent}._3uK2I0hi3JFTKnMUFHD2Pd{margin-top:6px}._3uK2I0hi3JFTKnMUFHD2Pd:after{border-bottom:3px solid #000;border-top:none;bottom:100%;top:auto}
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